The implementation of the pilot regions projects has shown some barriers and obstacles that have highlighted the opportunities but also difficulties to set up a Programme Delivery Unit (PDU) and kick-start a large scale programme for energy efficiency and renewable energy in buildings. These barriers are mainly of political, organisational, decisional and financial nature. The analysis of these barriers, their impact and possible ways of lifting them has allowed improving the guidance to project developers wishing to create and finance a PDU and to formulate some recommendations.